Epidemiological and clinicopathological study with analysis of risk factors of oral lesions in two distinct regions of brazilian northeast

Autores

  • Antonio Ernando Carlos Ferreira Junior Universidade Federal do Ceará
  • Paulo Goberlanio de Barros Silva
  • Maria Elisa Quesado Lima Verde Lima Verde
  • Fabrício Bitu Sousa
  • Mário Rogério Lima Mota
  • Ana Paula Negreiros Nunes Alves

DOI:

https://doi.org/10.59483/rfpp.v4n2112

Palavras-chave:

Epidemiology, Oral Diagnosis, Risk Factors

Resumo

Introduction: Geographic variations also contribute to the appearance of some oral lesions, such as lip cancer and actinic cheilosis. However, this association may be related to habits, environmental conditions and professional occupation found in different regions. Methods: An observational, cross-sectional and quantitative study was carried out. Data was collected from clinical records and histopathological reports of patients with oral lesions served in the 14th (semiarid region) and 16th (coastal region) Regional Health Coordinations (CRES) in the state of Ceará, between August 2010 and January 2012. Results: 110 patients were collected, the majority of whom were female (64.5%) and in their sixth decade of life (25.0%). The most prevalent histopathological diagnosis was fibroepithelial hyperplasia (40.9%), followed by squamous cell carcinoma, mucocele and traumatic fibroma (8.2%). No differences in the presentation of injuries among regions were found. Exposure to factors smoking (p=0.001), alcohol (p=0.047) and sun exposure (p=0.016), besides the use of hat and lip balm (p<0.05, OR= 5.6 and 19.9, respectively) were associated with prevention of malignant and potencial malignant lesions in both regions. Conclusions: No significant differences were found in the injury profile found when comparing the two regions, coastal and semi-arid. The importance of the preventive role of wearing hats and lip balms in reducing the prevalence of malignant neoplasms is highlighted.

Referências

Bhatnagar P, Rai S, Bhatnagar G, Kaur M, Goel S, Prabhat M. Prevalence study of oral mucosal lesions, mucosal variants, and treatment required for patients reporting to a dental school in North India: In accordance with WHO guidelines. J Family Community Med. 2013 Jan;20(1):41-8. doi: 10.4103/2230-8229.108183..

Warnakulasuriya S, Kerr AR. Oral Cancer Screening: Past, Present, and Future. J Dent Res. 2021 Nov;100(12):1313-1320. doi: 10.1177/00220345211014795. Epub 2021 May 26.

Tatli U, Erdoğan Ö, Uğuz A, Üstün Y, Sertdemır Y, Damlar İ. Diagnostic concordance characteristics of oral cavity lesions. ScientificWorldJournal. 2013 Dec 25;2013:785929. doi: 10.1155/2013/785929..

Gheno JN, Martins MA, Munerato MC, Hugo FN, Sant'ana Filho M, Weissheimer C, Carrard VC, Martins MD. Oral mucosal lesions and their association with sociodemographic, behavioral, and health status factors. Braz Oral Res. 2015;29:S1806-83242015000100289. doi: 10.1590/1807-3107BOR-2015.vol29.0093. Epub 2015 Aug 4. PMID: 26247518..

Silva LVO, Arruda JAA, Martelli SJ, Kato CNAO, Nunes LFM, Vasconcelos ACU, Tarquino SBC, Gomes APN, Gomez RS, Mesquita RA, Silveira MMF, Sobral, APV. A multicenter study of biopsied oral and maxillofacial lesions in a Brazilian pediatric population. Braz oral res [Internet]. 2018;32:e20. Available from: https://doi.org/10.1590/1807-3107bor-2018.vol32.0020

Dutra KL, Longo L, Grando LJ, Rivero ERC. Incidence of reactive hyperplastic lesions in the oral cavity: a 10 year retrospective study in Santa Catarina, Brazil. Braz J Otorhinolaryngol. 2019 Jul-Aug;85(4):399-407. doi: 10.1016/j.bjorl.2018.03.006. Epub 2018 Apr 17

Ali M, Sundaram A, Biopsied Oral Soft Tissue Lesions in Kuwait: A Six-Year Retrospective Analysis. Med Princ Pract. v.20, p. 569–575; 2012.

National Institute of Cancer - Instituto Nacional de Câncer (INCA), Coordenação de Prevenção e Vigilância. Estimativa 2023: incidência de câncer no Brasil - Estimate 2023: incidence of cancer in Brazil. Rio de Janeiro (Brasil): Instituto Nacional de Câncer; 2023.

Chiliti BA, Campos WG, Gallo CB, Lemos CA. Oral cancer analysis in a Brazilian city: interval between diagnosis and treatment. Braz Oral Res. 2022 May 2;36:e073

Nokovitch L, Maquet C, Crampon F, Taihi I, Roussel L-M, Obongo R, Virard F, Fervers B, Deneuve S. Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art. Journal of Clinical Medicine. 2023; 12(9):3264. https://doi.org/10.3390/jcm12093264

Campisi, G.; Margiotta, V. Oral mucosal lesions and risk habits among men in an Italian study population. J Oral Pathol Med., v.30, n.8, p. 20-28, 2001.

Barreto Rc, Paiva Ma, Soares Ms, Pereira Ga. Prevalência de Câncer Bucal nas Mesorregiões Paraibanas. Rev Bras Ciênc Saúde 2006; 10(1):9-16.

Hoffmann W, Latza U, Baumeister SE, Brünger M, Buttmann-Schweiger N, Hardt J, Hoffmann V, Karch A, Richter A, Schmidt CO, Schmidtmann I, Swart E, van den Berg N. Guidelines and recommendations for ensuring Good Epidemiological Practice (GEP): a guideline developed by the German Society for Epidemiology. Eur J Epidemiol. 2019 Mar;34(3):301-317. doi: 10.1007/s10654-019-00500-x. Epub 2019 Mar 4..

Cebeci AR, Gülşahi A, Kamburoglu K, Orhan BK, Oztaş B. Prevalence and distribution of oral mucosal lesions in an adult Turkish population. Med Oral Patol Oral Cir Bucal. 2009 Jun 1;14(6):E272-7. PMID: 19300376.

Lima IAB, Almeida RJL, Pontes-Silva A, Ribeiro BF, Figueiredo FWDS, Quaresma FRP, Maciel EDS. Epidemiological study on the lip and oral cavity cancer in Brazil: connecting science and clinical applicability. Rev Assoc Med Bras (1992). 2022 Sep;68(9):1337-1341. doi: 10.1590/1806-9282.20220806. PMID: 36228268; PMCID: PMC9575038.

Lopez P.M. E; Minarro-Del Moral, R. M.; Martinez-Garcia, C; Zanetti, R; Rosso, S; Serrano, S; Aneiros, J F; Jimenez-Puente, A; Redondo, M. Lifestyles, environmental and phenotypic factors associated with lip cancer: a case–control study in southern Spain. British Journal of Cancer, 2003 88 (11), 1702.

Souza L.R., Fonseca-Fonseca T., Oliveira-Santos C.C., Corrêa G.T.B., Santos F.B.G., Cardoso C.M., Sant’ana-Haikal D., Guimarães A.L.S., De Paula A.M.B. Lip squamous cell carcinoma in a Brazilian population: Epidemiological study and clinicopathological associations Med Oral Patol Oral Cir Bucal. 2011 16 (6):757-62.

Bertoja I.C., Tomazini J.G., Braosi A.P.R., Zielak J.C., Reis L.F.G., Giovanini A.F. Prevalência de lesões bucais diagnosticadas pelo Laboratório de Histopatologia do UnicenP. Rev Sul-Bras Odontol; 2007 4 (2): 41-46.

Marin H.J.I., Silveira M.M.F., Souza G.F.M., Pereira J.R.D. Lesões bucais: concordância diagnóstica na Faculdade de Odontologia de Pernambuco. Odontol Clín-Cient. out-dez; 2007 6( 4):315-18.

Dias Neto B., Medrado A.P., Reis S.R.A. levantamento epidemiológico dos diagnósticos histopatológicos de um centro de referência em patologia bucomaxilofacial em um período de 10 anos. Revista Bahiana de Odontologia, Salvador. 2012; 3 (1):3-15

Elani Hw, Harper S, Allison Pj, Bedos C, Kaufman Js. Socio-economic inequalities and oral health in Canada and the United States. Journal of Dental Research. 2012;91(9):865–70

Pereira T.T.M., Gaetti-Jardim E.M., Castillo K.A., Paes G.B., Barros R.S.G. Levantamento Epidemiológico das Doenças de Boca: Casuística de Dez Anos. Arch Health Invest.2013. 2 (3):15-20. 2013

Seyedmajidi M., Hamzehpoor M.,Bagheromoghaddam S., Localized lesions of oral cavity: a clinicopathological study of 107 cases. Research Journal of Medical Sciences, v.5, n. 2, p. 67-77. 2011

Shulman, J. D.; Beach, M. M.; Rivera-Hidalgo, F. The prevalence of oral mucosal lesions in U.S. adults. Data from the Third National Health and Nutrition Examination Survey, 1988-1994. JADA, 2004; 135:1279-1286.

Henrique Pr, Bazaga Júnior M, Araújo Vc, Junqueira Jlc, Furuse C. Prevalência de alterações da mucosa bucal em indivíduos adultos da população de Uberaba, Minas Gerais. RGO- Ver Gaúcha Odontol. 2009; 57(3): 261-7.

Vasconcelos AC, Aburad C, Lima IFP, Santos SMM, Freitas SAJ Filho, Franco A, Rode SM, Paranhos LR. A scientific survey on 1550 cases of oral lesions diagnosed in a Brazilian referral center. An Acad Bras Cienc. 2017 Jul-Sep;89(3):1691-1697. doi: 10.1590/0001-3765201720170006. Epub 2017 Aug 14.

Håkansson N, Floderus B, Gustavsson P, Feychting M, Hallin N. Occupational sunlight exposure and cancer incidence among Swedish construction workers. Epidemiology. 2001 Sep;12(5):552-7. doi: 10.1097/00001648-200109000-00015.

Kenborg L, Jørgensen AD, Budtz-Jørgensen E, Knudsen LE, Hansen J. Occupational exposure to the sun and risk of skin and lip cancer among male wage earners in Denmark: a population-based case-control study. Cancer Causes Control. 2010 Aug;21(8):1347-55. doi: 10.1007/s10552-010-9562-1. Epub 2010 Apr 11.

Dantas TS, de Barros Silva PG, Sousa EF, da Cunha MDP, de Aguiar ASW, Costa FWG, Mota MRL, Alves APNN, Sousa FB. Influence of Educational Level, Stage, and Histological Type on Survival of Oral Cancer in a Brazilian Population: A Retrospective Study of 10 Years Observation. Medicine (Baltimore). 2016 Jan;95(3):e2314. doi: 10.1097/MD.0000000000002314.

Li. L, Psoter WJ, Buxo CJ, Elias A, Cuadrado L, Morse DJ. Smoking and drinking in relation to oral potentially malignant disorders in Puerto Rico: a case-control study. BMC Cancer. 2011; 11, 324-342.

Talamini R, Vaccarella S, Barbone F, Tavani A, La Vecchia C, Herrero R, Muñoz N, Franceschi S. Oral hygiene, dentition, sexual habits and risk of oral cancer. Br J Cancer. 2000;83(9):1238-42

Alburqueque, R, López-López J, Mari-Roig A, Jané-Salas E, Chimenos-Kuster E, Santos JR. Relationship between squamous cell carcinoma of the anterior two thirds of the tongue and removable denture use: a pioneer study in a Portuguese population. Braz. Dent. J., Ribeirão Preto 2011, 22 (5).

Rotundo, LDB, Toporcov, TN, Biazevic, GH, Carvalho, MB, Kowalski, LP, & Antunes, JLF. Are recurrent denture-related sores associated with the risk of oral cancer? A case control study. Rev. bras. epidemiol., São Paulo 2013 Sep; 16 (3).

Halboub ES, Abdulhuq M, Al-Mandili A. Oral and pharyngeal cancers in Yemen: a retrospective study. East Mediterr Health J. 2012 Sep;18(9):985-91.

Rodriguez-Blanco I, Florez Á, Paredes-Suárez C, Rodríguez-Lojo R, González-Vilas D, Ramírez-Santos A, Paradela S, Suárez Conde I, Pereiro-Ferreirós M. Use of lip photoprotection in patients suffering from actinic cheilitis. Eur J Dermatol. 2019 Aug 1;29(4):383-386. doi: 10.1684/ejd.2019.3604. PMID: 31475909.

Souza Lucena EE, Costa DC, da Silveira EJ, Lima KC. Prevalence and factors associated to actinic cheilitis in beach workers. Oral Dis. 2012 Sep;18(6):575-9. doi: 10.1111/j.1601-0825.2012.01910.x. Epub 2012 Feb 15. PMID: 22335283.

Downloads

Publicado

25-06-2024

Como Citar

1.
Ferreira Junior AEC, Barros Silva PG de, Lima Verde MEQLV, Sousa FB, Mota MRL, Nunes Alves APN. Epidemiological and clinicopathological study with analysis of risk factors of oral lesions in two distinct regions of brazilian northeast. RFPP [Internet]. 25º de junho de 2024 [citado 21º de dezembro de 2024];4(2). Disponível em: https://revista.facpp.edu.br/index.php/rfpp/article/view/112

Edição

v. 4 n. 2 (2024)

Seção

Artigos

Licença

Copyright (c) 2024 Licença Creative Commons Attribution-ShareAlike 4.0 International License. Esta licença permite que outros remixem, ajustem e desenvolvam seu trabalho de forma não comercial, desde que creditem a autoria e licenciem suas novas criações sob os mesmos termos.

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution-ShareAlike 4.0 International License.

Esta licença permite que outros remixem, ajustem e desenvolvam seu trabalho de forma não comercial, desde que creditem a autoria e licenciem suas novas criações sob os mesmos termos.

Artigos mais lidos pelo mesmo(s) autor(es)